Mega-Thread: Coronavirus Pandemic

[stanley13s]

In the developed world sort of this year; after vaccinations.

And if we don't talk about possible mutations, right?

[Corvus]

And if we don't talk about possible mutations, right?

If this thing mutates so that vaccines don't work then it will be many years, if ever, we get back to normal.

[Underverse]

If this thing mutates so that vaccines don't work then it will be many years, if ever, we get back to normal.

Well now that the first RNA vaccine has been approved all it takes is a tiny adjustment to the nucleic acid sequence and you have a vaccine that works again. Approval times and clinical trials should be negligible as it's effectively the same vaccine. The only drawback will be PEG reactions, which should be ok for anyone who doesn't routinely take other medications with PEG.

[PACOX]

Hey folks, how long, do you think, would it take to get for all us, to the normal point again?

1 year minimum assuming the vaccines are permanent and the virus doesn't have seasonal variants. 3 - 5 years if the vaccines are short-term. In that time we will have hopefully developed better treatments so catching it won't me overcrowded hospitals and a roll of the dice.

Some people forget that they even if fatalities drop (hopefully that day will come) its due to an overstressed healthcare system that is putting everything it has into keeping people alive. That means others diseases will become more serve since there's only so much energy and resources that can go around. We're already seeing people not going in for stuff they should or serious conditions having to be triaged. That's before we get into the mental health of healthcares workers and the population in general.

The healthcare system afford people to say "well I'm just to live my life" and contribute to more waves. You don't need to be inside 24/7. You need to distance when outside, limit your social circle, not linger, and wear your damn mask.

[Felya]

1 year minimum assuming the vaccines are permanent and the virus doesn't have seasonal variants.

We are never returning to “normal”... well... we will get back to normal, about 10 years after we return to normal from 9/11... am still waiting for that one.

[PACOX]

The healthcare workers in our country start getting the vaccine now... idk why I feel so scared about the vaccines, I mean like it usually takes 2 - 3 years to develop a safe, high quality one, and this type of vaccine is extremely rushed.

It doesn't take that long. It takes that long to go through the legal and scientific hurdles while a treatment is just sitting on a shelf. The process is very inefficient.

That doesn't mean you shouldn't be wary of the vaccines though but they aren't as catastrophic as they seem. There are people who experience adverse effects. There's always the chance of the body reacting weirdly to mRNA but the chances of something happening are between low and out of control.

[Granyala]

You are confused between rushed and expedited.

While your points are correct and virtually unlimited resources + manpower + streamlined paperwork do make a huge difference, lets not forget that phase III studies are still in the early stages, so yes: the testing process itself has been shortened as well.
IIRC phase III deals with long term effects and is scheduled to run for 2 years.

Naturally, under normal circumstances, you would not get an approval for public use until said studies were finished but since we haven't seen widespread problems, the vaccines got an emergency approval by some countries.

[beanman12345]

While your points are correct and virtually unlimited resources + manpower + streamlined paperwork do make a huge difference, lets not forget that phase III studies are still in the early stages, so yes: the testing process itself has been shortened as well.
IIRC phase III deals with long term effects and is scheduled to run for 2 years.

Naturally, under normal circumstances, you would not get an approval for public use until said studies were finished but since we haven't seen widespread problems, the vaccines got an emergency approval by some countries.

No. Phase 3 is done for the ones that have been approved. That's why they've been approved. We're now in phase 4 to see how long term the immunity from them last. Others like J&J's vaccine are still on Phase 3 and haven't been approved are studying long term side effects.

[Forogil]

No. Phase 3 is done for the ones that have been approved. That's why they've been approved.

No, phase 3 isn't done - and to claim that they are approved is an over-simplification.

The phase 3 studies are still ongoing as planned, their original end-points were in 2022 and that still seems to be the plan: https://www.pfizer.com/news/press-re...vid-19-vaccine

The trial will continue to collect efficacy and safety data in participants for an additional two years.

(Some claim it's a phase 2/3 study; and FDA even that is an ongoing phase 1/2/3 study; one of the ways everything was sped up was that multiple phases run in parallel.)

Others like J&J's vaccine are still on Phase 3 and haven't been approved are studying long term side effects.

There are also multiple regulatory bodies in the world; Moderna is approved in the US, but currently not in the EU (probably will be tomorrow) - and it also makes sense that all studies continue until everyone has approved them; and even later.

Pfizer/BioNTech vaccine has emergency use authorization in the US and UK, and full authorization in the EU (and some additional European countries).

- - - Updated - - -

An additional factor that made it easier to get a quick vaccine is that the immune system actually works for this virus. A virus that the immune system normally doesn't handle that well, like HIV, would have been more complicated to handle.

[beanman12345]

Edit - oh it's anti-mask guy.

PFIZER AND BIONTECH CONCLUDE PHASE 3 STUDY OF COVID-19 VACCINE CANDIDATE, MEETING ALL PRIMARY EFFICACY ENDPOINTS

yeah phase 3 is done.

people, wear a mask, get the vaccine when you can. Don't be this guy^

[ldev]

So now that more and more people are getting sick and realizing that this shit was even less than a flu (I mean symptoms and "complications", not akshually technically, and, well, who woulda guessed with 30-50% people being asymptomatic that this is weak lol) - what will happen when a deadly virus hits? I think covid and it's response really fucked humanity - because next time people will be inclined to quarantine even less than they do now.

I just keep imagining during next pandemic two people in a pub:

-Oh they are quarantining us again, just like during covid back in 2020.
-Damn, covid was bullshit, I got covid, you got covid, it was nothing.
-Yea, we should go out to protest, this is another fucking bullshit.

gl hf containing people during a deadly virus outbreak after covid.

[Forogil]

PFIZER AND BIONTECH CONCLUDE PHASE 3 STUDY OF COVID-19 VACCINE CANDIDATE, MEETING ALL PRIMARY EFFICACY ENDPOINTS

In the

ongoing Phase 3 study

The trial will continue to collect efficacy and safety data in participants for an additional two years.

https://www.nytimes.com/interactive/...e-tracker.html still lists Pfizer/BioNTech in phase 2/3.

The actual study is: https://clinicaltrials.gov/ct2/show/NCT04368728

Estimated Primary Completion Date : July 30, 2021
Estimated Study Completion Date : January 27, 2023

Is it 2023 yet?

Or in summary: that phase 3 trial continue - some 24 primary (and 18 secondary) outcome measures are completed, while others need more time.

I see that you continue with inaccurate name-calling and barely reading head-lines.

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Oh, and I realized that the press release headline from Pfizer/BioNTech was very specific - and not as general as some believe.

The key parts are "primary" and "efficacy"; meaning that all secondary end-points are not met yet, and more importantly that all "primary safety" end-points aren't met either; as some of them include adverse reactions up to 6 months after the last dose of the vaccine.

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I just realized that some commented that an additional reason the vaccine are approved this fast was the sharp increase of cases in the last couple of months. Basically the trials require that a certain number of persons become naturally infected to see how effective it is - the more wide-spread the virus is the faster that goes.

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Naturally, under normal circumstances, you would not get an approval for public use until said studies were finished but since we haven't seen widespread problems, the vaccines got an emergency approval by some countries.

To clarify:

The US and the UK currently have emergency approvals.
However, the EU are described as "normal" approvals by many.

[Yunru]

1 dead person from vacine reported here. (older person)
Seems like 5% risk is quite real.

[beanman12345]

Oh and for those interested, Moderna is also done with phase 3.

At least for those who understand what "conclude" and "endpoint" mean.

though they'll have to start the process from the beginning for kids.

[postman1782]

So the "pharmacist" that left out hundreds of Moderna vaccines, believed that the vaccine could change DNA.

https://lawandcrime.com/covid-19-pan...ge-dna-police/

Not surprising.

[Gaidax]

Seems like we're starting to run out of vaccines after 1.5 shots were done. Starting Jan 16th no new jabs will be done and only 2nd ones will go through. So far it's only Phizer, Moderna is expected to come late January or February.

For now it's ~14% of country population done. It's still mostly 60+ only, with some exceptions, such as airport staff and teachers (there is a bit back and forth on that one). Some people, who should not be eligible, of course weaseled their way through either with cases of oversupply in some places or in some cases simple mismanagement.

[Forogil]

Oh and for those interested, Moderna is also done with phase 3.

In reality they are also continuing with their phase 3 trial, as only the primary efficacy analysis is complete.

They have thus not yet reached all secondary endpoints and all primary safety endpoints. When discussing whether a vaccine is safe the safety endpoints are kind of important.

The trial will continue to accrue additional data relevant to safety and efficacy even after an EUA is submitted. The final estimates of vaccine efficacy for both primary and secondary endpoints will depend on the totality of data that will accumulate to inform the final analysis.

At least for those who understand what "conclude" and "endpoint" mean.

Yes, the phase 3 studies continue as those that understand those words see; and in particular note that there are multiple endpoints - some are reached, many are not yet reached.

Here's that study: https://www.clinicaltrials.gov/ct2/show/NCT04470427

Estimated Primary Completion Date : October 27, 2022
Estimated Study Completion Date : October 27, 2022

Is the year 2022 yet?

Note that this vaccine is not yet approved by the EU.

[Logwyn]

1 dead person from vacine reported here. (older person)
Seems like 5% risk is quite real.

So the same chance to die from Covid as the vaccine? I'm still trying to figure out why we are sending kids back into school buildings.

[Gaidax]

Well after 1.5m jabs are done here, I heard only about like, 2 cases of severe allergic reaction. Certainly I don't have all the data, but if it would actually be anything significant - we would know by now.

Of course, it remains to be seen is long term, but short term - there do not seem to be issues.

[Poopymonster]

So the same chance to die from Covid as the vaccine? I'm still trying to figure out why we are sending kids back into school buildings.

Because children need the socialization and interactions with kids their own ages to help them develop properly. Those kids aren't going to bully themselves you know.