The more you can 100% optimally use manually the better, but if you start fucking up globals trying to fit stuff between them, then you should not bother.
I use Rabid, BW, Rapid Fire, Lifeblood manually, with Berserking just macroed to Stampede, but its cooldown being tracked so that I can use it anyway if I know I will not get a second Stampede. I use Synapse Springs simply macroed into everything.
In the case of Blood Fury, I haven't done the math on what it can line up with, but I guess you can take it out of your shot macros and try to use it manually and observe the situations you come across in a fight where you can delay (but only by a little bit) for benefit.