There's talk of using it for AoE with Sow the Seeds, the seeds will refresh it naturally anyway but you might not have many globals left to spray Agonies and UAs around so the damage increase is good. I'm not sure it's a massive loss on fewer targets, but frankly your rotation starts to feel very empty with that kind of build so I've not even tried. If you have the globals and the Shards, it might even be worth using Mana Tap now for 3-5 targets.