Allow me to counter:
Yes, we might be very insignificant in the larger picture. However, none of us can really do anything with the larger picture. That's why we keep ourselves to our "inner circles". Friends, family and those kind of "circles" To them, we're very significant. And that's what matters. I know that I am insignificant to some guy in America, but so is he to me! Being insignificant to the universe is NOTHING when I can be of significance to those who are significant to me<3