I watched this video a few days back and it's a pretty interesting take on the Fermi Paradox and what the galaxy would look like if humanity ever becomes a true spacefaring species in the event there are no other civilizations in the galaxy.
Basically the video talks about the concept of human speciation through natural evolution, genetic engineering or cybernetic enhancement and the possibility of us creating other alien civilizations by uplifting animal or alien species.
So, do you think this is a likely scenario? Humans diverging to the point of being unrecognizably humans and possibly not even realizing their origins on Earth (think how many people still react aggressively towards the Out of Africa Theory).