I got a theory about the future of V.
Spoilers about the Nomad ending and Misty.
It seems to be a happier ending. Romance Panam, drive with a Tank with her and the Nomads across the Border, once across hold hands etc. End credits roll with messages from the characters. (guessing a few days or weeks have passsed since leaving NC)
Most seem congratulatory, a few stand out though and V replies to non of them. Even Mother Welles, who seems to be a mother figure to V seems to be ignored.
1. Misty is accurate with her Card readings throughout the game. In the credits she predicts only good things for you. So chances are we get a "happily ever after" ending with V and whoever we romanced. However, she also says because of the distance it might not be very accurate. So who knows.
2. Panam is shrouded in a black background, her face and body hidden in black. She says she cares about you, is sad she cant be with you right now and promises to make it up to you. She might be infiltrating someplace (likely a Nomad Corporation, guild etc, since she says she is on Nomad business) trying to find a cure for V. She is maybe trying to hide her location from V, so he/she does not come looking for her, especially now with the health issue.
3. Judy is being ignored (she says V wont call her back) she also seems rather depressed(understandable after what happened to Evelyn. After the friendship the two form I cannot imagine V would ignore her unless he has a good reason or has no ability to reply to her. Maybe V cannot make contact with her because it would endanger her. I can imagine the NC Corpos being out for blood after the tower, and would hunt her down if they figured out she was involved with the heist that started it all.
I guess the next DLC will take place in Arizona and that V is their looking for a cure.(Will allow the reuse of the desert art assets). That is also were the Nomads were heading towards. V has keep radio silence because lots of people are after him now and those he cares about. Gangs,Corporations Investors (the news loading screen says stocks are going down rapidly and to sell while you can) are probably hunting him and those he knows in order to kill what they believe to be the new Johhny Silverhand.