Well, it makes sense to ignore the ending, given how horrifyingly retarded it was, but what they ended up going with doesn't make much sense either. They just made it trivially easy for just about anyone to travel between galaxies without the reapers being able to do anything about it, which means that... the milky way galaxy should be full of aliens traveling to it form other galaxies, including tons of warpgates built by said explorers as they arrive. The rest of the universe should also be filled with milky way species from older cycles who escaped or just left of their own to explore for reasons unrelated to the endless reaper purges. Never mind all the other stuff that adding this logically demands of the setting.
Can't say I'm surprised that none of it makes any sense, though. They really painted themselves into a corner with how stupid the final game was, so if they wanted another mass effect-like game set in the same setting then they'd have no choice but to do something that made no sense. Well, or they could just make the 'kill the reapers' the canon ending... but why take the easy way out when you can take the stupid way out instead? Although, even that leaves open all these other massive problems of logic that they've not in any way addressed... but then I guess most sci-fi tends to stop making sense really fast when you go beyond the limited scope of the original story.
I'm cautiously optimistic, though. Still liked the games; they were very competently put together outside of all the stupid shit they added to the third one. Hopefully Andromeda will be more like 1&2. Ideally 2, since I thought that was the best one. Man, they even shit on TIM. That story had so much potential and it just devolved into the most boring cliche... such an annoying ending to the trilogy.